Major recent advances in cancer biology have brought interactions between inflammatory and epithelial cells into sharp focus. Epithelial oncogenic alteration can predate tumor formation and may activate or inhibit inflammatory surveillance networks. The dynamics of this interaction dictate how a tumor may form, regress, or progress. This session will explore these dynamics, with a focus on strategies to manipulate the interaction of premalignant and malignant epithelial cells with infiltrating inflammatory cells to prevent or treat lung cancer.