The explosion of large data sets derived from high-throughput multi-omics technologies holds great promise for answering fundamental questions in lung health and disease. The integration of data sets generated by different technologies—such as combining epigenetic profiling with transcriptional profiling—poses significant challenges. This session aims to provide a vocabulary to aid in discussion of multi-omics integration; engender familiarity with literature on multi-omics technologies; and concretize conceptual and technical approaches to integration of multi-omics-derived data sets in lung health and disease.