Fluid administration is a key therapy in sepsis. Despite its long history, much uncertainty persists about how best to administer fluid. This session will cover six of the biggest questions on fluid administration in sepsis, including when to administer fluid, how to administer fluid, and when to consider diuresis or dialysis. Experts in the field will review the most recent evidence and offer answers to these questions. This session is of value to any clinician who treats sepsis, and any clinical or translational researcher who works in sepsis.