This symposium will provide the learner with a comprehensive overview of immune regulation by metabolic pathways in the context of respiratory diseases. The aim is to link immunometabolism and mitochondrial function or dysfunction to the understanding of protective or pathological immune responses in the lung. The influence of metabolism on host immunity and systemic inflammatory diseases will also be discussed. Individual speakers will review the concept and basic principles of immunometabolism, the crucial role of the mitochondria in these processes, and how the function of various immune cell types is affected by specific metabolic reprogramming and nutrient availability.