The results from the ProCESS, ProMISe, and ARISE clinical trials in sepsis have generated significant uncertainty regarding the optimal therapy for patients with sepsis. Recent studies investigating early fluid therapy and metabolic resuscitation with vitamin C have only added to this confusion. This symposium will provide an opportunity to discuss both cornerstone and novel therapies for patients with sepsis and will end with a talk by an expert in the field regarding how they treat patients in light of current evidence. This symposium will provide guidance to both clinicians and scientists regarding the state of the art in sepsis care and how to use this evidence to improve patient outcomes.