Event

Emerging evidence sheds light on the role of danger or damage associated molecular patterns (DAMPs), the host-derived endogenous signals, in many inflammatory lung diseases. Both mitochondrial and nuclear components, such as mitochondrial DNA and high-mobility group box 1 (HMGB1), when released into the extracellular milieu, can induce both innate and adaptive immune responses. These DAMPs can alter the resistance of host defense in both plants and animals to pathogens, causing cellular injury and lung diseases. The goal of this symposium is to highlight the recent advances in mitochondria and nuclear-derived DAMPs, particularly in their cell signaling, redox status, and the therapeutic potential of targeting these DAMPs in pulmonary diseases (acute lung injury, pulmonary infections, and COPD).