The prevailing focus within ‘personalized medicine’ emphasizes an individual’s genes and therapy-focused biology that insufficiently incorporates the important role of environmental factors in lung disease etiology. Including these factors allows for personalized health, a more preventive orientation. For example, a better understanding of the relationship between environmental exposure and the lung epigenome might lead to more efficient preventive measures. This symposium brings together experts who present data supporting a personalized approach to preventing lung disease.