Recent years have seen many multicentered pleural disease trials completed with immediate impact on clinical care. These studies have been published in high impact journals: including trials on malignant effusions (eg TIME-1 and -2 trials - both in JAMA), mesothelioma (SMART trial - Lancet Oncology; MAPPs and Meso-VATS - Lancet), and pleural infection (eg MIST-2 - NEJM), and pneumothorax. Several large trials eg the AMPLE-1, IPC-PLUS, ASAP, PLEASE and MIST-3 are completed and will report results in 2017/early 2018. The session will update the audience of the latest exciting advances from RCTs that impact care.