Please join us for an engaging and illuminating Clinical Issues™ symposium focused on evolving management strategies for severe cases of asthma. A faculty panel comprising 3 well-known experts in asthma research will review key diagnostic criteria; biomarkers and comorbidities that help elucidate severe phenotypes and shape therapeutic choices; and the mechanistic and clinical profiles associated with current and emerging biologic asthma therapies. A brief didactic introduction to each topic will set the stage for animated exchanges of faculty views, allowing each presenter to highlight actionable recommendations founded in the growing evidence base but filtered through the lens of the expert’s extensive clinical experience.